ARBs and ACE inhibitors are contraindicated in which condition?

ARBs and ACE inhibitors are contraindicated in which condition?

• A. Hypertension
• B. Diabetes mellitus
• C. Pregnancy
• D. Chronic kidney disease

Answer: (C)

ACE inhibitors and ARBs disrupt angiotensin II effects, which are essential for fetal kidney development. In pregnancy, especially after mid-gestation, these drugs can cause fetal kidney failure leading to oligohydramnios, skull hypoplasia, limb contractures, and can result in neonatal hypotension or death. Because of these serious risks, they are contraindicated during pregnancy. The other conditions listed do not require avoidance of these drugs. Hypertension is a common indication for ACE inhibitors and ARBs. In chronic kidney disease, they often help protect kidney function by reducing proteinuria, and in diabetes they can be beneficial for kidney protection if diabetic nephropathy is present.

ACE inhibitors and ARBs disrupt angiotensin II effects, which are essential for fetal kidney development. In pregnancy, especially after mid-gestation, these drugs can cause fetal kidney failure leading to oligohydramnios, skull hypoplasia, limb contractures, and can result in neonatal hypotension or death. Because of these serious risks, they are contraindicated during pregnancy.

The other conditions listed do not require avoidance of these drugs. Hypertension is a common indication for ACE inhibitors and ARBs. In chronic kidney disease, they often help protect kidney function by reducing proteinuria, and in diabetes they can be beneficial for kidney protection if diabetic nephropathy is present.